Up to 1.65 million women of childbearing age at risk for Zika

2016-07-25 18:33:21

CHICAGO As many as 1.65 million women of childbearing age in Central and Latin America are at risk of being infected with Zika, resulting in tens of thousands of pregnancies that could be affected by the mosquito-borne virus that is linked with severe birth defects.The projections, published on Monday in Nature Microbiology, are based on an enhanced model of the Zika outbreak. Prior modeling efforts that focus on the number of cases have been challenging because people infected with Zika often don't have symptoms.The new research takes into account prior outbreaks of similar viruses, mosquito transmission patterns, climate conditions, virus incubation periods, and the impact of herd immunity - which occurs when a high percentage of a population becomes immune to an infection.Herd immunity can extinguish an outbreak when so many people become immune - either naturally or through vaccination - that the virus no longer spreads efficiently.The researchers also calculated the potential impact of economic factors. According to study co-author Alex Perkins of University of Notre Dame, women in poorer areas are at greater risk for Zika because they are less likely to have screens on their windows and air conditioners - two factors that have a major influence on reducing exposure to mosquitoes that carry Zika.Given all these parameters, they estimate that up to 1.65 million women of childbearing age in Latin America and the Caribbean are at risk of contracting Zika in the first wave of the outbreak. "That is a cumulative number over the course of roughly the first two to three years of the outbreak," Perkins said. "We consider that to be an upper limit of what might be possible."Perkins said the estimate puts tens of thousands of babies at risk of developing the birth defect microcephaly or other issues related to being exposed to Zika in the womb.The model also predicts that Brazil will have three times more infections than any other affected country, due to its size and suitability for transmission. U.S. health officials have concluded that Zika infections in pregnant women can cause microcephaly, a birth defect marked by small head size that can lead to severe developmental problems in babies. The connection between Zika and microcephaly first came to light last fall in Brazil, which has now confirmed more than 1,600 cases of microcephaly that it considers to be related to Zika infections in the mothers. (Reporting by Julie Steenhuysen; Editing by Alan Crosby)

Novartis, world's top drugmaker, plays down Brexit threat

2016-07-19 10:39:03

ZURICH, July 19 Switzerland's Novartis, the world's biggest maker of prescription drugs, will continue to invest in Britain, despite the country's decision to leave the European Union, its chief executive said on Tuesday.Joe Jimenez also told reporters he expected the European Medicines Agency (EMA), currently based in London, to continue its work on approving new medicines in an "orderly" fashion, even though it is likely to have to move to a new location."The UK is an important market for us. There are many countries in Europe, namely Switzerland, which are not in the EU, and we continue to invest in those countries as well as in the EU," he said in a post-results call."We will continue to invest strongly in the UK despite the decision to exit the EU as we see very large areas of unmet medical need and the innovation Novartis brings can help patients in the UK." The sanguine comments from Jimenez, who is also president of the European Federation of Pharmaceutical Industries and Associations trade body, contrast with concerns expressed by some other pharmaceutical industry executives.The CEO of Spain's Almirall, for example, said earlier this month the relocation of the EMA threatened to disrupt the approval of new drugs and represented a medium and long-term concern. The UK pharmaceuticals trade association has also warned that having Britain outside the EU could undermine future investment, research and jobs in the country.Depending on the exact EU exit terms, Britain may have to develop its own domestic regulatory system, adding an extra layer of regulation and bureaucracy. The EMA, Europe's equivalent the U.S. Food and Drug Administration, currently approves medicines for all European Union countries from its headquarters in London's Canary Wharf financial district. Other European cities are already vying to be its new home.Drugmakers also face challenges and uncertainties across the Atlantic, with the U.S. market - the biggest and most profitable for the industry - facing increased pressure on prices.Jimenez said he was planning for a "more difficult" U.S. pricing environment going forward."We all have to plan for new pricing models in the U.S that could help us ensure sustainability of the system as the U.S. population ages. We are planning for a environment where there are not increases in price in the U.S.," he said. (Writing by Ben Hirschler; Editing by Mark Potter)

BRIEF-Transaction Co Ltd unit enters into basic agreement with ImageWorks Corporation for Baidu Map promotion in JP

2016-07-12 09:14:19

July 12 Transaction Co Ltd :* Says its unit TRANS. entered into basic agreement with ImageWorks Corporation, the Japan-based agency of Baidu Map* Says Baidu Map is a map service operated by Baidu Inc. * Says the unit will co-promote the Baidu Map in Japan Source text in Japanese:goo.gl/w7g0hTFurther company coverage: (Beijing Headline News)

Iraqis want crackdown on 'sleeper cells' after huge Baghdad bomb

2016-07-04 19:09:12

BAGHDAD The death toll from a suicide bombing in a Baghdad shopping district rose above 150 on Monday, fueling calls for security forces to crack down on Islamic State sleeper cells blamed for one of the worst ever single bombings in Iraq.Numbers rose as bodies were recovered from the rubble in the Karrada area of Baghdad, where a refrigerator truck packed with explosives blew up on Saturday night when people were out celebrating the holy month of Ramadan.By Monday afternoon the toll in Karrada stood at 151 killed and 200 wounded, according to police and medical sources. Rescuers and families were still looking for 35 missing people.Islamic State claimed the bombing, its deadliest in Iraq, saying it was a suicide attack. Another explosion struck in the same night, when a roadside bomb blew up in popular market of al-Shaab, a Shi'ite district in north Baghdad, killing two people.The attacks showed Islamic State can still strike in the heart of the Iraqi capital despite recent military losses, undermining Prime Minister Haider al-Abadi's declaration of victory last month when Iraqi forces dislodged the hardline Sunni insurgents from the nearby city of Falluja.Abadi's Shi'ite-led government ordered the offensive on Falluja in May after a series of deadly bombings in Shi'ite areas of Baghdad that it said originated from the Sunni Muslim city, about 50 km (30 miles) west of the capital.Falluja was the first Iraqi city captured by Islamic State in 2014, six months before it declared a caliphate over parts of Iraq and Syria. Since last year the insurgents have been losing ground to U.S.-backed Iraqi government forces and Iranian-backed Shi'ite militias. "Abadi has to have a meeting with the heads of national security, intelligence, the interior ministry and all sides responsible for security and ask them just one question: How can we infiltrate these groups?" said Abdul Kareem Khalaf, a former police Major General who advises the Netherlands-based European Centre for Counterterrorism and Intelligence Studies think tank. He said Islamic State, or Daesh, "has supporters or members everywhere - in Baghdad, Basra and Kurdistan. All it takes is for one house to have at least one man and you have a planning base and launch site for attacks of this type."In a sign of public outrage at the failure of the security services, Abadi was given an angry reception on Sunday when he toured Karrada, the district where he grew up, with residents throwing stones, empty buckets and even slippers at his convoy in gestures of contempt.He ordered new measures to protect Baghdad, starting with the withdrawal of fake bomb detectors that police have continued to use despite a scandal that broke out in 2011 about their sale to Iraq under his predecessor, Nuri al-Maliki.The hand-held devices were initially developed to find lost golf balls, and the British businessman who sold them to Iraq for $40 million was jailed in Britain in 2013. Abadi ordered that the fake devices be replaced by efficient detectors at the entrances to Baghdad and Iraq's provinces. Karrada, a largely Shi'ite district with a small Christian community and a few Sunni mosques, was busy at the time of the blast as people were eating out and shopping late during Ramadan, which ends this week with the Eid al-Fitr festival.As Iraq started observing three days of national mourning, rescuers continued digging through the rubble of a shopping mall believed to be the main target of the bombing, searching for bodies or possible survivors.Three bodies were pulled out in the morning from the basement of the three-story Al-Laith mall, which was reduced to a skeleton of charred steel and concrete by the blast. Its glass facades were blown out and its internal divider walls collapsed. Dozens of people gathered outside, many of them friends or relatives of missing. "I know my nephew is here because he called me to say he can't leave because of the fire in the building," said Mohammed al-Tai watching the rescuers at work."As Daesh retreats, it will shrink from so-called state and terrorist group to just terrorist group," said Baghdad-based security analyst Hisham al-Hashimi, author of "The World of Daesh".That will require an increased response from intelligence and security services, he said, as well as cooperation from Iraq's Sunni Muslims who have complained of marginalisation since the 2003 U.S. invasion to topple Saddam Hussein."Their input would be of utmost importance to unmask sleeper cells that could be operating from their areas," Hashimi said.Iraqi intelligence services announced on Monday the arrest of 40 "terrorists" suspected of forming a group to carry out attacks in Baghdad and the eastern Diyala province. (Writing by Maher Chmaytelli; Editing by Dominic Evans)

Supreme Court firmly backs abortion rights, tosses Texas law

2016-06-28 13:05:00

WASHINGTON The U.S. Supreme Court on Monday struck down a Texas abortion law imposing strict regulations on doctors and facilities in the strongest endorsement of abortion rights in America in more than two decades.The 5-3 ruling held that the Republican-backed 2013 Texas law placed an undue burden on women exercising their right under the U.S. Constitution to end a pregnancy, established in the court's landmark 1973 Roe v. Wade decision.The abortion providers who challenged the law said it was medically unnecessary and specifically intended to shut clinics. Texas officials said it was intended to protect women's health. The ruling means similar laws in other states are probably unconstitutional and could put in jeopardy other types of abortion restrictions enacted in various conservative states."The decision should send a loud signal to politicians that they can no longer hide behind sham rationales to shut down clinics and prevent a woman who has decided to end a pregnancy from getting the care she needs," said Jennifer Dalven, a lawyer with the American Civil Liberties Union.President Barack Obama, whose administration backed the abortion providers in the court challenge, said in a statement he was "pleased to see the Supreme Court protect women's rights and health" and that restrictions like those in Texas "harm women's health and place an unconstitutional obstacle in the path of a woman's reproductive freedom."Conservative Justice Anthony Kennedy joined the court's four liberal members in the ruling, with the remaining three conservatives dissenting. The court declared that both key provisions of the law - requiring abortion doctors to have difficult-to-obtain "admitting privileges" at a local hospital and requiring clinics to have costly hospital-grade facilities - violated a woman's right to an abortion.Writing for the court, liberal Justice Stephen Breyer said, "We conclude that neither of these provisions offers medical benefits sufficient to justify the burdens upon access that each imposes.""Each places a substantial obstacle in the path of women seeking a pre-viability abortion, each constitutes an undue burden on abortion access, and each violates the federal Constitution," Breyer added.Deferring to state legislatures over "questions of medical uncertainty is also inconsistent with this court's case law," Breyer added. The ruling in the case, Whole Woman's Health v. Hellerstedt, represented the most vigorous affirmation of abortion rights in the United States since a 1992 ruling affirmed a woman's right to have the procedure.On a warm sunny summer day, hundreds of people on both sides of the issue converged on the Supreme Court building, with abortion rights advocates dancing and celebrating after the ruling. "We're ecstatic. The reality is today women won," abortion rights activist Marcela Howell said.The law was passed by a Republican-led legislature and signed by a Republican governor in 2013. Ten states currently have admitting privileges requirements on the books while six have laws requiring hospital-grade facilities. Lower courts have blocked admitting privileges provisions in five states and halted facilities regulations in two states. "The decision erodes states’ lawmaking authority to safeguard the health and safety of women and subjects more innocent life to being lost. Texas' goal is to protect innocent life, while ensuring the highest health and safety standards for women," Republican Texas Governor Greg Abbott said.Since the law was passed, the number of abortion clinics in Texas, the second-most-populous U.S. state with about 27 million people, had dropped from 41 to 19.The Supreme Court has appeals pending in two cases involving admitting privilege laws in Mississippi and Wisconsin on which it could act as soon as Tuesday.     The Texas law required abortion doctors to have "admitting privileges," a type of formal affiliation, at a hospital within 30 miles (48 km) of the clinic so they can treat patients needing surgery or other critical care.The law also required clinic buildings to possess costly, hospital-grade facilities. These regulations covered numerous building features such as corridor width, the swinging motion of doors, floor tiles, parking spaces, elevator size, ventilation, electrical wiring, plumbing, floor tiling and even the angle that water flows from drinking fountains.PUBLIC OPINION SPLITAmericans remain closely divided over whether abortion should be legal. In a Reuters/Ipsos online poll involving 6,769 U.S. adults conducted from June 3 to June 22, 47 percent of respondents said abortion generally should be legal and 42 percent said it generally should be illegal. Views on abortion in the United States have changed very little over the decades, according to historical polling data.The last time the justices decided a major abortion case was nine years ago when they ruled 5-4 to uphold a federal law banning a late-term abortion procedure.Amy Hagstrom Miller, founder and CEO of Whole Woman’s Health, which led the challenge to the Texas law, said, "Every day Whole Woman’s Health treats our patients with compassion, respect and dignity - and today the Supreme Court did the same. We’re thrilled that today justice was served and our clinics stay open."Presumptive Democratic presidential nominee Hillary Clinton on Twitter called the ruling "a victory for women in Texas and across America.""This fight isn't over: The next president has to protect women's health. Women won't be 'punished' for exercising their basic rights," she said, a dig at presumptive Republican presidential nominee Donald Trump, who once suggested women who get illegal abortions should face "some sort of punishment." The presidential election is Nov. 8.Some U.S. states have pursued a variety of restrictions on abortion, including banning certain types of procedures, prohibiting it after a certain number of weeks of gestation, requiring parental permission for girls until a certain age, imposing waiting periods or mandatory counseling, and others."It's exceedingly unfortunate that the court has taken the ability to protect women’s health out of the hands of Texas citizens and their duly-elected representatives," Texas Attorney General Ken Paxton, a Republican, said in a statement.Chief Justice John Roberts, Justice Clarence Thomas and Justice Samuel Alito dissented. The normally nine-justice court was one member short after the Feb. 13 death of conservative Justice Antonin Scalia, who consistently opposed abortion in past rulings. (Reporting by Lawrence Hurley; Additional reporting by Adam DeRose, Jon Herskovitz and David Ingram; Editing by Will Dunham)

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